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Target
Integrase
Ligand
BDBM23399
Substrate
n/a
Meas. Tech.
ChEMBL_1925214 (CHEMBL4428286)
IC50
400±n/a nM
Citation
 Tang, J; Liu, F; Nagy, E; Miller, L; Kirby, KA; Wilson, DJ; Wu, B; Sarafianos, SG; Parniak, MA; Wang, Z 3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations. J Med Chem 59:2648-59 (2016) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM23399
Synonyms:
4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-dioxobutanoic acid | CHEMBL421353 | CHEMBL50605 | L-731988
Type:
Small organic molecule
Emp. Form.:
C15H12FNO4
Mol. Mass.:
289.2585
SMILES:
OC(=O)C(=O)CC(=O)c1cccn1Cc1ccc(F)cc1
Structure:
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