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Target
Histamine H1 receptor
Ligand
BDBM50089148
Substrate
n/a
Meas. Tech.
ChEBML_83769
IC50
23±n/a nM
Citation
 Upton, C; Osborne, RH; Jaffar, M Conformationally-restricted ligands for the histamine H1 receptor. Bioorg Med Chem Lett 10:1277-9 (2000) [PubMed]
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50089148
Synonyms:
((3R,4S)-1-Ethyl-4-hydroxy-4-phenyl-piperidin-3-yl)-phenyl-methanone | CHEMBL283169
Type:
Small organic molecule
Emp. Form.:
C20H23NO2
Mol. Mass.:
309.4021
SMILES:
CCN1CC[C@](O)([C@@H](C1)C(=O)c1ccccc1)c1ccccc1
Structure:
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