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Target
Delta-type opioid receptor
Ligand
BDBM50474150
Substrate
n/a
Meas. Tech.
ChEMBL_1926741 (CHEMBL4429813)
Ki
3.0±n/a nM
Citation
 Váradi, A; Marrone, GF; Palmer, TC; Narayan, A; Szabó, MR; Le Rouzic, V; Grinnell, SG; Subrath, JJ; Warner, E; Kalra, S; Hunkele, A; Pagirsky, J; Eans, SO; Medina, JM; Xu, J; Pan, YX; Borics, A; Pasternak, GW; McLaughlin, JP; Majumdar, S Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ?-Arrestin-2. J Med Chem 59:8381-97 (2016) [PubMed]  Article
Target
Name:
Delta-type opioid receptor
Synonyms:
DOR-1 | K56 | MSL-2 | OPIATE Delta | OPRD_MOUSE | Opioid receptors; mu and delta | Oprd1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40577.25
Organism:
MOUSE
Description:
P32300
Residue:
372
Sequence:
MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50474150
Synonyms:
CHEMBL58362
Type:
Small organic molecule
Emp. Form.:
C23H30N2O5
Mol. Mass.:
414.4947
SMILES:
[H][C@@]12C[C@]([H])(C(=C/OC)\C(=O)OC)[C@]([H])(CC)CN1CC[C@]21Nc2cccc(OC)c2C1=O
Structure:
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