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Target
Group XIIB secretory phospholipase A2-like protein
Ligand
BDBM50534272
Substrate
n/a
Meas. Tech.
ChEMBL_1928127 (CHEMBL4431199)
IC50
<14±n/a nM
Citation
 Giordanetto, F; Pettersen, D; Starke, I; Nordberg, P; Dahlström, M; Knerr, L; Selmi, N; Rosengren, B; Larsson, LO; Sandmark, J; Castaldo, M; Dekker, N; Karlsson, U; Hurt-Camejo, E Discovery of AZD2716: A Novel Secreted Phospholipase A ACS Med Chem Lett 7:884-889 (2016) [PubMed]  Article
Target
Name:
Group XIIB secretory phospholipase A2-like protein
Synonyms:
GXIIB | GXIII sPLA2-like | Group XIIB secretory phospholipase A2-like protein | Group XIII secretory phospholipase A2-like protein | PG12B_HUMAN | PLA2G12B | PLA2G13 | PLA2G13 | sPLA2-GXIIB
Type:
PROTEIN
Mol. Mass.:
21657.53
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
195
Sequence:
MKLASGFLVLWLSLGGGLAQSDTSPDTEESYSDWGLRHLRGSFESVNSYFDSFLELLGGKNGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL
  
Inhibitor
Name:
BDBM50534272
Synonyms:
CHEMBL4593409
Type:
Small organic molecule
Emp. Form.:
C24H23NO3
Mol. Mass.:
373.4443
SMILES:
C[C@H](Cc1cccc(c1)-c1cc(Cc2ccccc2)ccc1C(N)=O)C(O)=O |r|
Structure:
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