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Target
Proteasome subunit beta type-1
Ligand
BDBM11318
Substrate
n/a
Meas. Tech.
ChEMBL_1930126 (CHEMBL4433377)
IC50
240±n/a nM
Citation
 Golonko, A; Pienkowski, T; Swislocka, R; Lazny, R; Roszko, M; Lewandowski, W Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system. Eur J Med Chem 167:291-311 (2019) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM11318
Synonyms:
1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione | 1,3,8-trihydroxy-6-methylanthra-9,10-quinone | CHEMBL289277 | Emodin | US20230364057, Compound 242 | med.21724, Compound 24
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Structure:
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