Reaction Details  Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50535296
Substrate
n/a
Meas. Tech.
ChEMBL_1930187 (CHEMBL4433438)
IC50
520±n/a nM
Citation
 Wang, D; Hu, M; Li, X; Zhang, D; Chen, C; Fu, J; Shao, S; Shi, G; Zhou, Y; Wu, S; Zhang, T Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease. Eur J Med Chem 168:207-220 (2019) [PubMed]  Article
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50535296
Synonyms:
CHEMBL4516496
Type:
Small organic molecule
Emp. Form.:
C22H25NO4
Mol. Mass.:
367.4382
SMILES:
CCN(C)CCCOc1ccc2c(c1)occ(-c1ccc(OC)cc1)c2=O
Structure:
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