Reaction Details  Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50535399
Substrate
n/a
Meas. Tech.
ChEMBL_1930356 (CHEMBL4433607)
EC50
18±n/a nM
Citation
 Stefanucci, A; Lei, W; Pieretti, S; Dimmito, MP; Luisi, G; Novellino, E; Nowakowski, M; Ko?mi?ski, W; Mirzaie, S; Zengin, G; Streicher, JM; Mollica, A Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis:  ACS Med Chem Lett 10:450-456 (2019) [PubMed]  Article
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50535399
Synonyms:
CHEMBL4473857
Type:
Small organic molecule
Emp. Form.:
C52H58F6N10O14
Mol. Mass.:
1161.0659
SMILES:
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1C\C=C\C[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)NNC(=O)[C@H](Cc2ccccc2)NC(=O)CNC1=O |r,t:28|
Structure:
Search PDB for entries with ligand similarity: