Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50535398
Substrate
n/a
Meas. Tech.
ChEMBL_1930355 (CHEMBL4433606)
Ki
495±n/a nM
Citation
Stefanucci, A; Lei, W; Pieretti, S; Dimmito, MP; Luisi, G; Novellino, E; Nowakowski, M; Ko?mi?ski, W; Mirzaie, S; Zengin, G; Streicher, JM; Mollica, A Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis: ACS Med Chem Lett 10:450-456 (2019) [PubMed] Article
More Info.:
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
Inhibitor
Name:
BDBM50535398
Synonyms:
CHEMBL4434948
Type:
Small organic molecule
Emp. Form.:
C52H58F6N10O14
Mol. Mass.:
1161.0659
SMILES:
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1C\C=C/C[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)NNC(=O)[C@H](Cc2ccccc2)NC(=O)CNC1=O |r,c:28|