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Target
Cathepsin B
Ligand
BDBM50092297
Substrate
n/a
Meas. Tech.
ChEBML_47433
Ki
7300±n/a nM
Citation
 Lubisch, W; Hofmann, HP; Treiber, HJ; Möller, A Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors. Bioorg Med Chem Lett 10:2187-91 (2001) [PubMed]
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50092297
Synonyms:
1-(Naphthalene-2-carbonyl)-piperidine-4-carboxylic acid (1-benzyl-2-carbamoyl-2-oxo-ethyl)-amide | CHEMBL69715
Type:
Small organic molecule
Emp. Form.:
C27H27N3O4
Mol. Mass.:
457.521
SMILES:
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(CC1)C(=O)c1ccc2ccccc2c1
Structure:
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