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Target
Geranylgeranyl pyrophosphate synthase
Ligand
BDBM25259
Substrate
n/a
Meas. Tech.
ChEMBL_1935622 (CHEMBL4481381)
IC50
280±n/a nM
Citation
 Malwal, SR; Chen, L; Hicks, H; Qu, F; Liu, W; Shillo, A; Law, WX; Zhang, J; Chandnani, N; Han, X; Zheng, Y; Chen, CC; Guo, RT; AbdelKhalek, A; Seleem, MN; Oldfield, E Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis. J Med Chem 62:2564-2581 (2019) [PubMed]  Article
Target
Name:
Geranylgeranyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:
Homooctamer; transferase
Mol. Mass.:
34867.94
Organism:
Homo sapiens (Human)
Description:
Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:
300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
  
Inhibitor
Name:
BDBM25259
Synonyms:
3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium | Bisphpshonate-715 | bisphosphonate, 15
Type:
Small organic molecule
Emp. Form.:
C17H31NO7P2
Mol. Mass.:
423.3781
SMILES:
CCCCCCCCCCOc1ccc[n+](CC(P(O)(O)=O)P(O)([O-])=O)c1
Structure:
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