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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50092993
Substrate
n/a
Meas. Tech.
ChEBML_138412
Ki
23±n/a nM
Citation
 Kozlowski, JA; Lowe, DB; Guzik, HS; Zhou, G; Ruperto, VB; Duffy, RA; McQuade, R; Crosby, G; Taylor, LA; Billard, W; Binch, H; Lachowicz, JE Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor. Bioorg Med Chem Lett 10:2255-7 (2001) [PubMed]
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50092993
Synonyms:
1-Cyclohexyl-4-{2,2,2-trifluoro-1-[4-(4-methoxy-benzenesulfinyl)-phenyl]-ethyl}-piperazine | CHEMBL70464
Type:
Small organic molecule
Emp. Form.:
C25H31F3N2O2S
Mol. Mass.:
480.586
SMILES:
COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C(F)(F)F
Structure:
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