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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50537370
Substrate
n/a
Meas. Tech.
ChEMBL_1936197 (CHEMBL4481956)
IC50
40200±n/a nM
Citation
 Xu, JF; Wang, TT; Yuan, Q; Duan, YT; Xu, YJ; Lv, PC; Wang, XM; Yang, YS; Zhu, HL Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase. Bioorg Med Chem 27:1509-1516 (2019) [PubMed]  Article
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM50537370
Synonyms:
CHEMBL4545197
Type:
Small organic molecule
Emp. Form.:
C18H13NO2S2
Mol. Mass.:
339.431
SMILES:
O=C(CN1C(=S)S\C(=C\c2ccccc2)C1=O)c1ccccc1
Structure:
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