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Target
Histone deacetylase 1
Ligand
BDBM50537478
Substrate
n/a
Meas. Tech.
ChEMBL_1936361 (CHEMBL4482120)
IC50
5.9±n/a nM
Citation
 Zhang, Q; Lv, J; He, F; Yu, C; Qu, Y; Zhang, X; Xu, A; Wu, J Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors. Bioorg Med Chem 27:1595-1604 (2019) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50537478
Synonyms:
CHEMBL4574697
Type:
Small organic molecule
Emp. Form.:
C27H23ClN4O4
Mol. Mass.:
502.949
SMILES:
ONC(=O)\C=C\c1ccc(cc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)Nc1ccc(Cl)cc1
Structure:
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