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Target
Histone deacetylase 11
Ligand
BDBM50537475
Substrate
n/a
Meas. Tech.
ChEMBL_1936364 (CHEMBL4482123)
IC50
3229±n/a nM
Citation
 Zhang, Q; Lv, J; He, F; Yu, C; Qu, Y; Zhang, X; Xu, A; Wu, J Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors. Bioorg Med Chem 27:1595-1604 (2019) [PubMed]  Article
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50537475
Synonyms:
CHEMBL4563800
Type:
Small organic molecule
Emp. Form.:
C27H23IN4O4
Mol. Mass.:
594.4004
SMILES:
ONC(=O)\C=C\c1ccc(cc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)Nc1ccc(I)cc1
Structure:
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