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Target
Histone deacetylase 8
Ligand
BDBM50537479
Substrate
n/a
Meas. Tech.
ChEMBL_1936363 (CHEMBL4482122)
IC50
281±n/a nM
Citation
 Zhang, Q; Lv, J; He, F; Yu, C; Qu, Y; Zhang, X; Xu, A; Wu, J Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors. Bioorg Med Chem 27:1595-1604 (2019) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50537479
Synonyms:
CHEMBL4592929
Type:
Small organic molecule
Emp. Form.:
C27H23BrN4O4
Mol. Mass.:
547.4
SMILES:
ONC(=O)\C=C\c1ccc(cc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)Nc1cccc(Br)c1
Structure:
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