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Target
Histone deacetylase 1
Ligand
BDBM50537754
Substrate
n/a
Meas. Tech.
ChEMBL_1971343 (CHEMBL4604161)
IC50
5100±n/a nM
Citation
 Kaur, N; Fang, YC; Lee, HY; Singh, A; Nepali, K; Lin, MH; Yeh, TK; Lai, MJ; Chan, L; Tu, YK; Banerjee, S; Hu, CJ; Liou, JP Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. Eur J Med Chem 187:0 (2020) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50537754
Synonyms:
CHEMBL4634931
Type:
Small organic molecule
Emp. Form.:
C22H26ClN3O3
Mol. Mass.:
415.913
SMILES:
ONC(=O)CCCC(=O)NCCCN1c2ccccc2CCc2ccc(Cl)cc12
Structure:
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