Reaction Details  Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50537749
Substrate
n/a
Meas. Tech.
ChEMBL_1971332 (CHEMBL4604150)
IC50
8620±n/a nM
Citation
 Kaur, N; Fang, YC; Lee, HY; Singh, A; Nepali, K; Lin, MH; Yeh, TK; Lai, MJ; Chan, L; Tu, YK; Banerjee, S; Hu, CJ; Liou, JP Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. Eur J Med Chem 187:0 (2020) [PubMed]  Article
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50537749
Synonyms:
CHEMBL4640986
Type:
Small organic molecule
Emp. Form.:
C25H24ClN3O3
Mol. Mass.:
449.929
SMILES:
ONC(=O)c1ccc(cc1)C(=O)NCCCN1c2ccccc2CCc2ccc(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: