Reaction Details  Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50537754
Substrate
n/a
Meas. Tech.
ChEMBL_1971339 (CHEMBL4604157)
IC50
1850±n/a nM
Citation
 Kaur, N; Fang, YC; Lee, HY; Singh, A; Nepali, K; Lin, MH; Yeh, TK; Lai, MJ; Chan, L; Tu, YK; Banerjee, S; Hu, CJ; Liou, JP Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. Eur J Med Chem 187:0 (2020) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50537754
Synonyms:
CHEMBL4634931
Type:
Small organic molecule
Emp. Form.:
C22H26ClN3O3
Mol. Mass.:
415.913
SMILES:
ONC(=O)CCCC(=O)NCCCN1c2ccccc2CCc2ccc(Cl)cc12
Structure:
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