Reaction Details  Report a problem with these data
Target
Bone morphogenetic protein 1
Ligand
BDBM50093843
Substrate
n/a
Meas. Tech.
ChEBML_158893
IC50
3600±n/a nM
Citation
 Dankwardt, SM; Billedeau, RJ; Lawley, LK; Abbot, SC; Martin, RL; Chan, CS; Van Wart, HE; Walker, KA Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase. Bioorg Med Chem Lett 10:2513-6 (2001) [PubMed]
Target
Name:
Bone morphogenetic protein 1
Synonyms:
BMP-1 | BMP1 | BMP1_HUMAN | Mammalian tolloid protein | PCOLC | PCP | Procollagen C-proteinase | mTld
Type:
PROTEIN
Mol. Mass.:
111254.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_518962
Residue:
986
Sequence:
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK
  
Inhibitor
Name:
BDBM50093843
Synonyms:
(2R,3S)-3-Methyl-2-(3-phenethyl-ureido)-pentanoic acid [(R)-1-hydroxycarbamoyl-2-(1H-indol-2-yl)-ethyl]-amide | CHEMBL83439
Type:
Small organic molecule
Emp. Form.:
C26H33N5O4
Mol. Mass.:
479.5713
SMILES:
CC[C@H](C)[C@@H](NC(=O)NCCc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: