Reaction Details  Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50094088
Substrate
n/a
Meas. Tech.
ChEMBL_214707 (CHEMBL817841)
IC50
51±n/a nM
Citation
 Kondo, K; Ogawa, H; Shinohara, T; Kurimura, M; Tanada, Y; Kan, K; Yamashita, H; Nakamura, S; Hirano, T; Yamamura, Y; Mori, T; Tominaga, M; Itai, A Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template. J Med Chem 43:4388-97 (2000) [PubMed]
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50094088
Synonyms:
CHEMBL136790 | [2-Chloro-4-(3-methyl-pyrrolidin-1-yl)-phenyl]-(2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-methanone
Type:
Small organic molecule
Emp. Form.:
C22H25ClN2O
Mol. Mass.:
368.9
SMILES:
CC1CCN(C1)c1ccc(C(=O)N2CCCCc3ccccc23)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: