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Target
Cathepsin K
Ligand
BDBM50095488
Substrate
n/a
Meas. Tech.
ChEMBL_48324 (CHEMBL663314)
Ki
380±n/a nM
Citation
 Falgueyret, JP; Oballa, RM; Okamoto, O; Wesolowski, G; Aubin, Y; Rydzewski, RM; Prasit, P; Riendeau, D; Rodan, SB; Percival, MD Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. J Med Chem 44:94-104 (2001) [PubMed]
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50095488
Synonyms:
1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile | CHEMBL8517
Type:
Small organic molecule
Emp. Form.:
C12H9N3
Mol. Mass.:
195.22
SMILES:
N#CN1Cc2cc3ccccc3nc2C1
Structure:
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