Reaction Details  Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50539742
Substrate
n/a
Meas. Tech.
ChEMBL_1979085 (CHEMBL4612220)
Ki
>10000±n/a nM
Citation
 Kochanowska-Karamyan, AJ; Araujo, HC; Zhang, X; El-Alfy, A; Carvalho, P; Avery, MA; Holmbo, SD; Magolan, J; Hamann, MT Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge  J Nat Prod 83:1092-1098 (2020) [PubMed]  Article
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50539742
Synonyms:
CHEMBL4642292
Type:
Small organic molecule
Emp. Form.:
C15H15BrN2
Mol. Mass.:
303.197
SMILES:
Cc1nccc2-c3ccc(Br)cc3NC(C)(C)c12
Structure:
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