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Target
Cyclin-dependent kinase 19
Ligand
BDBM50540078
Substrate
n/a
Meas. Tech.
ChEMBL_1980149 (CHEMBL4613411)
IC50
100±n/a nM
Citation
 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures. Eur J Med Chem 164:615-639 (2019) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 19
Synonyms:
CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028
Type:
Serine/Threonine protein kinase
Mol. Mass.:
56816.68
Organism:
Homo sapiens (Human)
Description:
Q9BWU1
Residue:
502
Sequence:
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
  
Inhibitor
Name:
BDBM50540078
Synonyms:
CHEMBL4639890
Type:
Small organic molecule
Emp. Form.:
C30H36N2O3
Mol. Mass.:
472.6184
SMILES:
[H][C@@]12CC[C@H](c3ccc4ccncc4c3)[C@@]1(C)CC=C1C=C3[C@@H](O)[C@H](O)[C@H](C[C@]33CC[C@@]21O3)N(C)C |r,t:21,23|
Structure:
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