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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50540121
Substrate
n/a
Meas. Tech.
ChEMBL_1980753 (CHEMBL4614015)
Ki
27±n/a nM
Citation
 Slack, RD; Ku, TC; Cao, J; Giancola, JB; Bonifazi, A; Loland, CJ; Gadiano, A; Lam, J; Rais, R; Slusher, BS; Coggiano, M; Tanda, G; Newman, AH Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability. J Med Chem 63:2343-2357 (2020) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50540121
Synonyms:
CHEMBL4649604
Type:
Small organic molecule
Emp. Form.:
C28H32F2N2O2S
Mol. Mass.:
498.628
SMILES:
O[C@H](CN1CCN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Structure:
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