Reaction Details  Report a problem with these data
Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50540719
Substrate
n/a
Meas. Tech.
ChEMBL_1982643 (CHEMBL4615905)
EC50
570±n/a nM
Citation
 Marino, S; Finamore, C; Biagioli, M; Carino, A; Marchianò, S; Roselli, R; Giorgio, CD; Bordoni, M; Di Leva, FS; Novellino, E; Cassiano, C; Limongelli, V; Zampella, A; Festa, C; Fiorucci, S GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis. ACS Med Chem Lett 11:818-824 (2020) [PubMed]  Article
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM50540719
Synonyms:
CHEMBL4643368
Type:
Small organic molecule
Emp. Form.:
C24H39NO2
Mol. Mass.:
373.572
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])C[C@@](C)(O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC#N |r|
Structure:
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