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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50096925
Substrate
n/a
Meas. Tech.
ChEBML_62001
IC50
>1000±n/a nM
Citation
 Davies, HM; Ren, P; Kong, N; Sexton, T; Childers, SR Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl. Bioorg Med Chem Lett 11:487-9 (2001) [PubMed]
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50096925
Synonyms:
3-[4-(1-Methyl-5-phenyl-1H-pyrrol-2-yl)-phenyl]-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid ethyl ester | CHEMBL145151
Type:
Small organic molecule
Emp. Form.:
C27H30N2O2
Mol. Mass.:
414.5393
SMILES:
CCOC(=O)C1C2CCC(CC1c1ccc(cc1)-c1ccc(-c3ccccc3)n1C)N2 |THB:3:5:30:7.8,12:11:30:7.8|
Structure:
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