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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50097027
Substrate
n/a
Meas. Tech.
ChEBML_71725
IC50
32±n/a nM
Citation
 Chu, L; Lo, JL; Yang, YT; Cheng, K; Smith, RG; Fisher, MH; Wyvratt, MJ; Goulet, MT SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists. Bioorg Med Chem Lett 11:515-7 (2001) [PubMed]
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50097027
Synonyms:
CHEMBL149181 | Piperazine-1,4-dicarboxylic acid 2-(3,5-dimethyl-phenyl)-3-{2-[4-(4-hydroxy-phenyl)-butylamino]-ethyl}-1H-indol-5-yl ester ethyl ester
Type:
Small organic molecule
Emp. Form.:
C36H44N4O5
Mol. Mass.:
612.7584
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)Oc1ccc2[nH]c(c(CCNCCCCc3ccc(O)cc3)c2c1)-c1cc(C)cc(C)c1
Structure:
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