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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50541331
Substrate
n/a
Meas. Tech.
ChEMBL_1984153 (CHEMBL4617559)
Ki
600±n/a nM
Citation
 Gapil Tiamas, S; Daressy, F; Abou Samra, A; Bignon, J; Steinmetz, V; Litaudon, M; Fourneau, C; Hoong Leong, K; Ariffin, A; Awang, K; Desrat, S; Roussi, F Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50541331
Synonyms:
CHEMBL4636501
Type:
Small organic molecule
Emp. Form.:
C19H25NO2
Mol. Mass.:
299.4073
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6]-1=[#6]-[#6]-[#6@@H](-[#6@H](-[#6]-1)-c1ccccc1)-[#6](=O)-[#7]-[#8] |r,t:6|
Structure:
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