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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50541350
Substrate
n/a
Meas. Tech.
ChEMBL_1984153 (CHEMBL4617559)
Ki
>23000±n/a nM
Citation
 Gapil Tiamas, S; Daressy, F; Abou Samra, A; Bignon, J; Steinmetz, V; Litaudon, M; Fourneau, C; Hoong Leong, K; Ariffin, A; Awang, K; Desrat, S; Roussi, F Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50541350
Synonyms:
CHEMBL4633307
Type:
Small organic molecule
Emp. Form.:
C19H24O2
Mol. Mass.:
284.3927
SMILES:
CC1(C)CCCC2=C1C[C@H]([C@@H](C2)c1ccccc1)C(O)=O |r,c:6|
Structure:
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