Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50098547
Substrate
n/a
Meas. Tech.
ChEMBL_3755 (CHEMBL620755)
Ki
708±n/a nM
Citation
 Linnanen, T; Brisander, M; Unelius, L; Rosqvist, S; Nordvall, G; Hacksell, U; Johansson, AM Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists. J Med Chem 44:1337-40 (2001) [PubMed]
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50098547
Synonyms:
(R)-Trifluoro-methanesulfonic acid 2-(6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-yl)-3-trifluoromethanesulfonyloxy-phenyl ester | CHEMBL282413
Type:
Small organic molecule
Emp. Form.:
C25H19F6NO6S2
Mol. Mass.:
607.542
SMILES:
CN1CCc2cccc-3c2[C@H]1Cc1cccc(c-31)-c1c(OS(=O)(=O)C(F)(F)F)cccc1OS(=O)(=O)C(F)(F)F |wD:10.11,(14.3,-16.35,;14.3,-14.82,;15.64,-14.08,;15.64,-12.52,;14.33,-11.75,;14.33,-10.22,;12.99,-9.42,;11.65,-10.19,;11.65,-11.75,;12.99,-12.52,;12.99,-14.05,;11.65,-14.82,;10.31,-14.05,;9,-14.82,;7.66,-14.05,;7.66,-12.52,;9,-11.75,;10.31,-12.52,;8.93,-10.06,;7.56,-9.39,;6.32,-10.29,;4.91,-9.62,;5.9,-8.47,;3.67,-10.51,;4.79,-8.08,;6.06,-7.22,;3.41,-7.45,;4.79,-6.55,;7.44,-7.86,;8.71,-7,;10.08,-7.67,;10.21,-9.17,;11.74,-8.69,;11.93,-7.16,;10.69,-6.23,;13.34,-7.73,;13.34,-6.55,;13.53,-5.05,;14.77,-6.3,;11.97,-5.18,)|
Structure:
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