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Target
Serine/threonine-protein kinase D2
Ligand
BDBM50542117
Substrate
n/a
Meas. Tech.
ChEMBL_1985973 (CHEMBL4619379)
IC50
102±n/a nM
Citation
 Atobe, M; Serizawa, T; Yamakawa, N; Takaba, K; Nagano, Y; Yamaura, T; Tanaka, E; Tazumi, A; Bito, S; Ishiguro, M; Kawanishi, M Discovery of 4,6- and 5,7-Disubstituted Isoquinoline Derivatives as a Novel Class of Protein Kinase C ? Inhibitors with Fragment-Merging Strategy. J Med Chem 63:7143-7162 (2020) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase D2
Synonyms:
KPCD2_HUMAN | PKD2 | PRKD2
Type:
Protein
Mol. Mass.:
96755.22
Organism:
Homo sapiens (Human)
Description:
Q9BZL6
Residue:
878
Sequence:
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
  
Inhibitor
Name:
BDBM50542117
Synonyms:
CHEMBL4640042
Type:
Small organic molecule
Emp. Form.:
C20H22N4
Mol. Mass.:
318.4155
SMILES:
Nc1cccc(c1)-c1cc(NC2CCCNC2)c2ccncc2c1
Structure:
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