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Target
Transporter
Ligand
BDBM50099224
Substrate
n/a
Meas. Tech.
ChEMBL_143106 (CHEMBL749356)
Ki
4769±n/a nM
Citation
 Davies, HM; Gilliatt, V; Kuhn, LA; Saikali, E; Ren, P; Hammond, PS; Sexton, T; Childers, SR Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites. J Med Chem 44:1509-15 (2001) [PubMed]
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50099224
Synonyms:
1-[3-(4-Ethyl-naphthalen-1-yl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-propan-1-one | CHEMBL285039
Type:
Small organic molecule
Emp. Form.:
C23H29NO
Mol. Mass.:
335.4825
SMILES:
CCC(=O)C1C2CCC(CC1c1ccc(CC)c3ccccc13)N2C |THB:11:10:23:6.7,2:4:23:6.7|
Structure:
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