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Target
Nuclear receptor ROR-gamma
Ligand
BDBM392006
Substrate
n/a
Meas. Tech.
ChEMBL_1987160 (CHEMBL4620707)
IC50
222±n/a nM
Citation
 Gege, C; Albers, M; Kinzel, O; Kleymann, G; Schlüter, T; Steeneck, C; Hoffmann, T; Xue, X; Cummings, MD; Spurlino, J; Milligan, C; Fourie, AM; Edwards, JP; Leonard, K; Coe, K; Scott, B; Pippel, D; Goldberg, SD Optimization and biological evaluation of thiazole-bis-amide inverse agonists of ROR?t. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM392006
Synonyms:
US10301272, Example 6/4
Type:
Small organic molecule
Emp. Form.:
C29H39N3O4S2
Mol. Mass.:
557.768
SMILES:
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)NCC(C)(C)O)c2ccccc12
Structure:
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