Reaction Details 
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Histamine H2 receptor
Ligand
BDBM50543288
Substrate
n/a
Meas. Tech.
ChEMBL_1988833 (CHEMBL4622380)
Ki
>100±n/a nM
Citation
Biselli, S; Alencastre, I; Tropmann, K; Erdmann, D; Chen, M; Littmann, T; Maia, AF; Gomez-Lazaro, M; Tanaka, M; Ozawa, T; Keller, M; Lamghari, M; Buschauer, A; Bernhardt, G Fluorescent H ACS Med Chem Lett 11:1521-1528 (2020) [PubMed] ArticleMore Info.:
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2_RAT | Hrh2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40269.37
Organism:
RAT
Description:
HISTAMINE H2 HRH2 RAT::P25102
Residue:
358
Sequence:
MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
Inhibitor
Name:
BDBM50543288
Synonyms:
CHEMBL4638742
Type:
Small organic molecule
Emp. Form.:
C27H37N7O2
Mol. Mass.:
491.6284
SMILES:
CNc1ccccc1C(=O)NCCN\C(NCCCOc1cccc(CN2CCCCC2)c1)=N/C#N
Structure:
