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Target
C-C chemokine receptor type 3
Ligand
BDBM50100081
Substrate
n/a
Meas. Tech.
ChEBML_41921
IC50
500±n/a nM
Citation
 Dhanak, D; Christmann, LT; Darcy, MG; Keenan, RM; Knight, SD; Lee, J; Ridgers, LH; Sarau, HM; Shah, DH; White, JR; Zhang, L Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2. Bioorg Med Chem Lett 11:1445-50 (2001) [PubMed]
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50100081
Synonyms:
CHEMBL284576 | Naphthalene-1-carboxylic acid {(S)-1-[(S)-1-(4-methoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-thiazol-4-yl-ethyl}-amide
Type:
Small organic molecule
Emp. Form.:
C27H26N4O4S
Mol. Mass.:
502.585
SMILES:
COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2cscn2)NC(=O)c2cccc3ccccc23)cc1
Structure:
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