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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50102014
Substrate
n/a
Meas. Tech.
ChEBML_201982
Ki
7.5±n/a nM
Citation
 Meagher, KL; Mewshaw, RE; Evrard, DA; Zhou, P; Smith, DL; Scerni, R; Spangler, T; Abulhawa, S; Shi, X; Schechter, LE; Andree, TH Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors. Bioorg Med Chem Lett 11:1885-8 (2001) [PubMed]
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50102014
Synonyms:
3-(4-Benzylamino-cyclohexyl)-1H-indole-5-carbonitrile | CHEMBL291739
Type:
Small organic molecule
Emp. Form.:
C22H23N3
Mol. Mass.:
329.4381
SMILES:
N#Cc1ccc2[nH]cc([C@@H]3CC[C@@H](CC3)NCc3ccccc3)c2c1 |wU:9.8,12.15,(-3.24,-6.28,;-1.9,-7.04,;-.57,-7.81,;-.6,-9.37,;.73,-10.14,;2.08,-9.39,;3.55,-9.88,;4.46,-8.64,;3.57,-7.39,;4.04,-5.93,;5.58,-5.64,;6.04,-4.17,;5.02,-3.01,;3.5,-3.34,;3.04,-4.8,;5.51,-1.56,;7,-1.26,;8.02,-2.4,;7.53,-3.84,;8.56,-5.01,;10.07,-4.68,;10.56,-3.24,;9.54,-2.07,;2.1,-7.86,;.75,-7.07,)|
Structure:
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