Reaction Details  Report a problem with these data
Target
Transient receptor potential cation channel subfamily V member 4
Ligand
BDBM50545036
Substrate
n/a
Meas. Tech.
ChEMBL_1994275 (CHEMBL4628170)
EC50
0.500000±n/a nM
Citation
 Lawhorn, BG; Brnardic, EJ; Behm, DJ Recent advances in TRPV4 agonists and antagonists. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Transient receptor potential cation channel subfamily V member 4
Synonyms:
TRPV4_MOUSE | Trp12 | Trpv4 | Vrl2 | Vroac
Type:
PROTEIN
Mol. Mass.:
98032.61
Organism:
Mus musculus
Description:
ChEMBL_1514430
Residue:
871
Sequence:
MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADEVVVPLDNLGNPNCDGHQQGYAPKWRTDDAPL
  
Inhibitor
Name:
BDBM50545036
Synonyms:
CHEMBL4632531
Type:
Small organic molecule
Emp. Form.:
C28H34N4O6S2
Mol. Mass.:
586.723
SMILES:
CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)N1CCN(CC1)C(=O)[C@H](CO)NS(=O)(=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: