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Target
Adenosine receptor A3
Ligand
BDBM50545322
Substrate
n/a
Meas. Tech.
ChEMBL_1994852 (CHEMBL4628747)
Ki
2679±n/a nM
Citation
 Varano, F; Catarzi, D; Vincenzi, F; Pasquini, S; Pelletier, J; Lopes Rangel Fietto, J; Espindola Gelsleichter, N; Sarlandie, M; Guilbaud, A; Sévigny, J; Varani, K; Colotta, V Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50545322
Synonyms:
CHEMBL4642713
Type:
Small organic molecule
Emp. Form.:
C22H22N6O3S
Mol. Mass.:
450.513
SMILES:
CCOC(=O)c1ccc(cc1)N1CCN(CC1)c1nc(N)c2nc(sc2n1)-c1ccco1
Structure:
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