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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM424912
Substrate
n/a
Meas. Tech.
ChEMBL_1996277 (CHEMBL4630172)
IC50
>80000±n/a nM
Citation
Gehling, VS; McGrath, JP; Duplessis, M; Khanna, A; Brucelle, F; Vaswani, RG; Côté, A; Stuckey, J; Watson, V; Cummings, RT; Balasubramanian, S; Iyer, P; Sawant, P; Good, AC; Albrecht, BK; Harmange, JC; Audia, JE; Bellon, SF; Trojer, P; Levell, JR Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors. ACS Med Chem Lett 11:1213-1220 (2020) [PubMed] Article
More Info.:
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
Inhibitor
Name:
BDBM424912
Synonyms:
2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclopropyl)amino)-2-azaspiro[3.3]heptan-2-yl)ethanol | US10517849, Compound 1 | US11013718, Compound 1 | US11547695, Compound 1
Type:
Small organic molecule
Emp. Form.:
C21H30N2O
Mol. Mass.:
326.4757
SMILES:
CC\C(=C/c1ccccc1)[C@@H]1C[C@H]1NC1CC2(C1)CN(CCO)C2 |r|