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Target
Tryptase beta-2
Ligand
BDBM50103810
Substrate
n/a
Meas. Tech.
ChEBML_210702
Ki
13000±n/a nM
Citation
 Dener, JM; Wang, VR; Rice, KD; Gangloff, AR; Kuo, EY; Newcomb, WS; Putnam, D; Wong, M Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors. Bioorg Med Chem Lett 11:2325-30 (2001) [PubMed]
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50103810
Synonyms:
3-[(4-Carbamimidoyl-benzoylamino)-methyl]-piperidine-1-carboxylic acid (3,3-diphenyl-propyl)-amide | CHEMBL76579
Type:
Small organic molecule
Emp. Form.:
C30H35N5O2
Mol. Mass.:
497.6312
SMILES:
NC(=N)c1ccc(cc1)C(=O)NCC1CCCN(C1)C(=O)NCCC(c1ccccc1)c1ccccc1
Structure:
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