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Target
Tryptase beta-2
Ligand
BDBM50103815
Substrate
n/a
Meas. Tech.
ChEBML_210702
Ki
870±n/a nM
Citation
 Dener, JM; Wang, VR; Rice, KD; Gangloff, AR; Kuo, EY; Newcomb, WS; Putnam, D; Wong, M Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors. Bioorg Med Chem Lett 11:2325-30 (2001) [PubMed]
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50103815
Synonyms:
CHEMBL74695 | Piperazine-1,4-dicarboxylic acid (3,3-diphenyl-propyl)-amide 4-guanidino-benzylamide
Type:
Small organic molecule
Emp. Form.:
C29H35N7O2
Mol. Mass.:
513.6339
SMILES:
[#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-[#6]-[#6]-[#6](-c2ccccc2)-c2ccccc2)cc1
Structure:
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