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Target
C-C chemokine receptor type 5
Ligand
BDBM50104220
Substrate
n/a
Meas. Tech.
ChEBML_49701
IC50
45±n/a nM
Citation
 Finke, PE; Meurer, LC; Oates, B; Shah, SK; Loebach, JL; Mills, SG; MacCoss, M; Castonguay, L; Malkowitz, L; Springer, MS; Gould, SL; DeMartino, JA Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes. Bioorg Med Chem Lett 11:2469-73 (2001) [PubMed]
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50104220
Synonyms:
1'-[3-(3-chlorophenyl)-4-methyl(phenyl)sulfonamidobutyl]-3-oxospiro[2,3-dihydro-1H-isoindole-1,4'-(hexahydropyridine)] | CHEMBL310305
Type:
Small organic molecule
Emp. Form.:
C29H32ClN3O3S
Mol. Mass.:
538.101
SMILES:
CN(C[C@@H](CCN1CCC2(CC1)NC(=O)c1ccccc21)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
Structure:
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