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Target
M-phase inducer phosphatase 2
Ligand
BDBM50106492
Substrate
n/a
Meas. Tech.
ChEMBL_49028 (CHEMBL662067)
IC50
16000±n/a nM
Citation
 Lazo, JS; Aslan, DC; Southwick, EC; Cooley, KA; Ducruet, AP; Joo, B; Vogt, A; Wipf, P Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem 44:4042-9 (2001) [PubMed]
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50106492
Synonyms:
2-(6-Chloro-5,8-dioxo-5,8-dihydro-quinolin-7-ylamino)-3-(1H-indol-3-yl)-propionic acid | CHEMBL334812
Type:
Small organic molecule
Emp. Form.:
C20H14ClN3O4
Mol. Mass.:
395.796
SMILES:
OC(=O)C(Cc1c[nH]c2ccccc12)=Nc1c(O)c2ncccc2c(O)c1Cl |w:14.16|
Structure:
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