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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50106506
Substrate
n/a
Meas. Tech.
ChEMBL_214523 (CHEMBL819515)
IC50
>10000±n/a nM
Citation
 Lazo, JS; Aslan, DC; Southwick, EC; Cooley, KA; Ducruet, AP; Joo, B; Vogt, A; Wipf, P Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem 44:4042-9 (2001) [PubMed]
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50106506
Synonyms:
6-Chloro-7-{4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazin-1-yl}-quinoline-5,8-dione | CHEMBL131657
Type:
Small organic molecule
Emp. Form.:
C17H20ClN3O4
Mol. Mass.:
365.811
SMILES:
OCCOCCN1CCN(CC1)C1=C(Cl)C(=O)c2cccnc2C1=O |c:13|
Structure:
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