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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50548356
Substrate
n/a
Meas. Tech.
ChEMBL_2021861 (CHEMBL4675674)
IC50
0.200000±n/a nM
Citation
 Grimster, NP; Gingipalli, L; Barlaam, B; Su, Q; Zheng, X; Watson, D; Wang, H; Simpson, I; Pike, A; Balazs, A; Boiko, S; Ikeda, TP; Impastato, AC; Jones, NH; Kawatkar, S; Kemmitt, P; Lamont, S; Patel, J; Read, J; Sarkar, U; Sha, L; Tomlinson, RC; Wang, H; Wilson, DM; Zehnder, TE; Wang, L; Wang, P; Goldberg, FW; Shao, W; Fawell, S; Dry, H; Dowling, JE; Edmondson, SD Optimization of a series of potent, selective and orally bioavailable SYK inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50548356
Synonyms:
CHEMBL4792651
Type:
Small organic molecule
Emp. Form.:
C22H24FN9O
Mol. Mass.:
449.4841
SMILES:
CNC(=O)c1nc(C)n2ccc(Nc3nccc(n3)-n3cc(cn3)[C@@H]3C[C@@H](F)CN3C)cc12 |r|
Structure:
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