Reaction Details Report a problem with these data
Target
Microsomal triglyceride transfer protein large subunit
Ligand
BDBM50107774
Substrate
n/a
Meas. Tech.
ChEMBL_103136 (CHEMBL712306)
IC50
20±n/a nM
Citation
Ksander, GM; deJesus, R; Yuan, A; Fink, C; Moskal, M; Carlson, E; Kukkola, P; Bilci, N; Wallace, E; Neubert, A; Feldman, D; Mogelesky, T; Poirier, K; Jeune, M; Steele, R; Wasvery, J; Stephan, Z; Cahill, E; Webb, R; Navarrete, A; Lee, W; Gibson, J; Alexander, N; Sharif, H; Hospattankar, A Diaminoindanes as microsomal triglyceride transfer protein inhibitors. J Med Chem 44:4677-87 (2001) [PubMed]
More Info.:
Target
Name:
Microsomal triglyceride transfer protein large subunit
Synonyms:
MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit
Type:
PROTEIN
Mol. Mass.:
99365.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_971724
Residue:
894
Sequence:
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
Inhibitor
Name:
BDBM50107774
Synonyms:
4,6-Dimethyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-(thiophene-2-sulfonylamino)-indan-5-yl]-amide | CHEMBL139834
Type:
Small organic molecule
Emp. Form.:
C29H25F3N2O3S2
Mol. Mass.:
570.646
SMILES:
Cc1cc(C)c(-c2ccc(cc2)C(F)(F)F)c(c1)C(=O)Nc1ccc2C[C@H](Cc2c1)NS(=O)(=O)c1cccs1