Reaction Details  Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50108346
Substrate
n/a
Meas. Tech.
ChEBML_146500
Ki
398±n/a nM
Citation
 Yu, H; Prisinzano, T; Dersch, CM; Marcus, J; Rothman, RB; Jacobson, AE; Rice, KC Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. Bioorg Med Chem Lett 12:165-8 (2001) [PubMed]
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50108346
Synonyms:
CHEMBL295295 | Indole Derivative
Type:
Small organic molecule
Emp. Form.:
C24H24N2O2
Mol. Mass.:
372.4596
SMILES:
C[C@@H]1C2C3Cc4ccc(O)c5O[C@@H](c6[nH]c7ccccc7c16)C2(CCN3C)c45 |TLB:10:27:2:25.23.24|
Structure:
Search PDB for entries with ligand similarity: