Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50108660
Substrate
n/a
Meas. Tech.
ChEMBL_201433 (CHEMBL809836)
Ki
2.2±n/a nM
Citation
 Maier, CA; Wünsch, B Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. J Med Chem 45:438-48 (2002) [PubMed]
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50108660
Synonyms:
1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(hexahydropyridine)]-3-ol | CHEMBL137990
Type:
Small organic molecule
Emp. Form.:
C20H23NO2
Mol. Mass.:
309.4021
SMILES:
OC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Structure:
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