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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50110524
Substrate
n/a
Meas. Tech.
ChEBML_139772
Ki
0.300000±n/a nM
Citation
 Kozlowski, JA; Zhou, G; Tagat, JR; Lin, SI; McCombie, SW; Ruperto, VB; Duffy, RA; McQuade, RA; Crosby, G; Taylor, LA; Billard, W; Binch, H; Lachowicz, JE Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands. Bioorg Med Chem Lett 12:791-4 (2002) [PubMed]
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50110524
Synonyms:
4-Cyclohexyl-1-[4-(4-methoxy-benzenesulfonyl)-benzyl]-2-methyl-piperazine | CHEMBL165439
Type:
Small organic molecule
Emp. Form.:
C25H34N2O3S
Mol. Mass.:
442.614
SMILES:
COc1ccc(cc1)S(=O)(=O)c1ccc(CN2CCN(C[C@H]2C)C2CCCCC2)cc1
Structure:
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