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Target
Histone deacetylase 8
Ligand
BDBM50551232
Substrate
n/a
Meas. Tech.
ChEMBL_2030962 (CHEMBL4685120)
IC50
1510±n/a nM
Citation
 Ojha, R; Nepali, K; Chen, CH; Chuang, KH; Wu, TY; Lin, TE; Hsu, KC; Chao, MW; Lai, MJ; Lin, MH; Huang, HL; Chang, CD; Pan, SL; Chen, MC; Liou, JP Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo. Eur J Med Chem 190:0 (2020) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50551232
Synonyms:
CHEMBL4790559
Type:
Small organic molecule
Emp. Form.:
C26H33N3O6
Mol. Mass.:
483.5567
SMILES:
CC(C)c1cc(C(=O)N2Cc3ccc(NC(=O)CCCCCCC(=O)NO)cc3C2)c(O)cc1O
Structure:
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